MITOCHONDRIAL NEUROT
MITOCHONDRIAL NEUROTOXINS AND OLIGODENDROCYTES/ MYELIN: THE HUMAN NEUROTOXIC PROCESS OF HEXACHLOROPHENE
Hexachlorophene is a mitochondrial neurotoxin that is especially toxic to developing oligodendrocytes. Myelin with water-filled spaces or vacuoles is a biomarker for hexachlorophene effects.
One of the ways in which hexachlorophene differs from other mitochondrial neurotoxins is the locations in the brain where it affects white and gray matter. Hexachlorophene is toxic to the cerebellum, the hippocampus and the brainstem among other areas of the brain. One of the most consistent findings in both human and animal research with hexachlorophene is its toxicity to the cerebellum.
Research with humans in the late 60s and early 70s showed hexachlorophene’s neurotoxicity to babies.An epidemiological study in France found that babies who received talcum powder with hexachlorophene in excessive amounts, died. Upon autopsy, they showed characteristic hexachlorophene abnormalities in their myelin. About the same time, in America, research with babies and young children were showing examples of hexachlorophene related neurotoxicity. As a result of this hexachlorophene use was severely restricted, essentially limited to adults.
One of those who participated in this research explained how difficult it was to do such research on such a widely used medical product. It would seem that the difficulty must have continued. One would expect more follow-up research on the possible long-term effects of hexachlorophene on those who received it at the vulnerable periods of their lives.
Two things have happened since that time. One is that those who received hexachlorophene early in their lives are now in their 30s, 40s, 50s, and 60s. Long-term effects on those who were most vulnerable are now possible. The second thing has to do with brain imaging advancements. The assessment of the long-term effects of hexachlorophene on both gray and white matter in the brain seems possible.
Hexachlorophene is a mitochondrial neurotoxin that is especially toxic to developing oligodendrocytes. Myelin with water-filled spaces or vacuoles is a biomarker for hexachlorophene effects.
One of the ways in which hexachlorophene differs from other mitochondrial neurotoxins is the locations in the brain where it affects white and gray matter. Hexachlorophene is toxic to the cerebellum, the hippocampus and the brainstem among other areas of the brain. One of the most consistent findings in both human and animal research with hexachlorophene is its toxicity to the cerebellum.
Research with humans in the late 60s and early 70s showed hexachlorophene’s neurotoxicity to babies.An epidemiological study in France found that babies who received talcum powder with hexachlorophene in excessive amounts, died. Upon autopsy, they showed characteristic hexachlorophene abnormalities in their myelin. About the same time, in America, research with babies and young children were showing examples of hexachlorophene related neurotoxicity. As a result of this hexachlorophene use was severely restricted, essentially limited to adults.
One of those who participated in this research explained how difficult it was to do such research on such a widely used medical product. It would seem that the difficulty must have continued. One would expect more follow-up research on the possible long-term effects of hexachlorophene on those who received it at the vulnerable periods of their lives.
Two things have happened since that time. One is that those who received hexachlorophene early in their lives are now in their 30s, 40s, 50s, and 60s. Long-term effects on those who were most vulnerable are now possible. The second thing has to do with brain imaging advancements. The assessment of the long-term effects of hexachlorophene on both gray and white matter in the brain seems possible.
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